Generation of oxygen radicals and mechanisms of injury prevention.
نویسندگان
چکیده
منابع مشابه
Generation of oxygen radicals and mechanisms of injury prevention.
Exposure to crystalline silica can result in damage to the lung parenchyma and scarring that can lead to fibrosis. Pulmonary damage may be the direct consequence of toxic interaction between quartz particles and cell membranes, or it may be due to silica-induced production of oxidant species by pulmonary phagocytes, that in turn overwhelms pulmonary antioxidant systems and causes lung injury. D...
متن کاملOxygen radicals, inflammation, and tissue injury.
Inflammatory reactions often result in the activation and recruitment of phagocytic cells (e.g., neutrophils and/or tissue macrophages) whose products result in injury to the tissue. In killing of endothelial cells by activated neutrophils as well as in lung injury produced by either activated neutrophils or activated macrophages there is evidence that H2O2 and iron play a role. HO. may be a ke...
متن کاملOxygen Radicals in Cerebral Vascular Injury
George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury. Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 1985 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.57.4.508 1985;57:508-516 Circ Res. http://circres.ahajournals.org/conte...
متن کاملGeneration of Reactive Oxygen Radicals through Bioactivation of Mitomycin Antibiotics1
Mitomycin C (MC) is a naturally occurring anticancer agent which has been shownto be more cytotoxicto hypoxictumor cells than to their aerobic counterparts. The mechanism of action of this agent is thought to involvebiologicalreductiveactivation,to a speciesthat alkylutes DNA. A comparisonof the cytotoxicityof MC to EMT6 tumor cells with that of the structural analogues porfiromycin(PM), .•V-...
متن کاملGeneration of reactive oxygen radicals through bioactivation of mitomycin antibiotics.
Mitomycin C (MC) is a naturally occurring anticancer agent which has been shown to be more cytotoxic to hypoxic tumor cells than to their aerobic counterparts. The mechanism of action of this agent is thought to involve biological reductive activation, to a species that alkylates DNA. A comparison of the cytotoxicity of MC to EMT6 tumor cells with that of the structural analogues porfiromycin (...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1994
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.94102s1065